Development of novel mucoadhesive gels containing nanoparticle for buccal administration of dexamethasone

This study aimed to develop promising and innovative mucoadhesive gel systems containing dexamethasone-loaded nanoparticle increase the effectiveness of treatment for oral precancerous lesions reduce side effects. In this respect, a formulation was prepared by using emulsification/solvent evaporation method. The has high zeta potential (-10.3±0.5 mV), low particle size (218.42±2.1), polydispersity index (0.070±0.014) encapsulation efficiency (95.018±2.982%). To improve mucosal retention time, dispersed in gellan gum. developed gels offered appropriate pH value, drug content, suitable mechanical performance viscosity administration. All formulations exhibited plastic flow typical gel-type spectra after determined frequency value. extended release as intended these systems. Cytotoxicity tested MTT assay human epithelioid carcinoma cell (HeLa) vitro. showed that blank were non-toxic cells. It observed bioactivity free dexamethasone potentiated HeLa Results from indicate are effective local lesions. Our findings worthy further studies.